Nefro - 24-3 - MIOLO.indd
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چکیده
Mycophenolate mofetil (MMF) is a potent immunosuppressive agent initially used in renal transplantation, but positive experience in the field of solid organ transplantation has made the drug attractive for the treatment of several autoimmune diseases. MMF targets the de novo purine biosynthesis pathway by noncompetitive inhibition of inosine monophosphate dehydrogenase, acting against the proliferation of T and B lymphocytes1. It is generally well tolerated and the most prominent adverse effects are nausea, vomiting, diarrhoea and haematological side effects2. Although hepatotoxicity has been rarely reported in the literature, there are some cases describing hepatic side effects of MMF2,3 that may be life threatening4. The authors present a case of fulminant acute hepatitis in a patient with lupus nephritis under recent treatment with mycophenolate mofetil.
منابع مشابه
Nefro - 26-3 - MIOLO.indd
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متن کاملNefro - 26-3 - MIOLO.indd
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متن کاملNefro - 24-2 - MIOLO.indd
There is a dearth of information on the prevalence and clinical characteristics of adult polycystic kidney disease (APKD) in Nigeria. Earlier studies in the tropical developing countries have reported either the rarity or very low prevalence of this disease and more importantly as a cause of renal failure, but there are hardly any such studies focussing on the pattern of APKD in renal disease p...
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تاریخ انتشار 2010